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A CROSS-SECTIONAL STUDY OF VITAMIN-D AND CALCIUM LEVELS IN PATIENTS LIVING WITH VIRAL HEPATIC INFECTIONS IN BENIN CITY, NIGERIA

Authors

  • E. E. Bessong Physiology Department, Ebonyi State University, Abakaliki, Nigeria
  • B. I. G. Adejumo Department of Medical Laboratory Science, University of Benin, Benin City
  • M. Idiaghe Department of Medical Laboratory Science, University of Benin, Benin City
  • E. O. Akhaumere Department of Chemical Pathology, National Hospital, Abuja
  • S. Uzor Physiology Department, Ebonyi State University, Abakaliki, Nigeria
  • F. O. Oyakhire Department of Medical Laboratory Science, College of Health Sciences, Joseph Ayo Babalola University, Ikeji Arakeji, Osun state
  • U. Dimkpa Physiology Department, Nnewi Campus, Nnamdi Azikiwe University, Awka, Nigeria
  • O. N. Abdulrahman Department of Medical Laboratory Science, College of Health Technology, Offa, Kwara state
  • U. I. Abdulkadir Department of Medical Laboratory Science, Federal University, Lafia, Nasarawa state

DOI:

https://doi.org/10.52417/ojbr.v4i2.526

Keywords:

Vitamin-D Deficiency, Hypocalcemia, Liver Infection, Hepatitis, Lifestyle

Abstract

The occurrence of vitamin D (25-(OH)D) insufficiency and hypocalcemia is associated with instances of chronic liver diseases. This investigation aimed to ascertain the prevalence of hypocalcemia and 25-(OH)D deficiency in people afflicted with viral liver infections and evaluate their serum calcium and 25-(OH)D concentrations to their respective characteristics. Forty-two individuals, with ages ranging from 20 to 70 years participated in the study. Within the sample population, a total of 29 individuals were diagnosed with hepatitis virus. The remaining thirteen participants consisted of healthy controls who were residents of Benin City.  Blood samples were collected from the participants, followed by centrifugation to separate the serum. The resulting serum was then stored at a temperature of -20 degrees Celsius. The amounts of calcium and vitamin D were quantified using Calcium AMP/CPC tests and vitamin-D ELISA kits, respectively. The findings of the study indicated that 54.8% of the participants exhibited a deficiency in vitamin D, while 11.9% of the participants displayed hypocalcemia. A significant (p <0.001) decrease in calcium and 25-(OH)D levels was also observed among patients diagnosed with hepatitis A, B, and C compared to the control group. People who took 25-(OH)D supplements, had significantly higher calcium levels (p < 0.001) than people who did not take supplements. Based on our research, it seems likely that giving 25-(OH)D supplements to people with viral liver infections could help them get better in future programs aimed at treating vitamin D deficiency and low calcium levels.

Published

2023-12-08

How to Cite

Bessong, E. E., Adejumo, B. I. G., Idiaghe, M., Akhaumere, E. O., Uzor, S., Oyakhire, F. O., Dimkpa, U., Abdulrahman, O. N., & Abdulkadir, U. I. (2023). A CROSS-SECTIONAL STUDY OF VITAMIN-D AND CALCIUM LEVELS IN PATIENTS LIVING WITH VIRAL HEPATIC INFECTIONS IN BENIN CITY, NIGERIA. Open Journal of Bioscience Research (ISSN: 2734-2069), 4(2), 13-28. https://doi.org/10.52417/ojbr.v4i2.526

Issue

Vol. 4 No. 2 (2023): OJBR 2023 Second Issue

Section

Articles

Copyright (c) 2023 Bessong et al.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.